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JUSTINE LENGRAND 2014-2015
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N.
Nature. 2015 Aug 20;524(7565):361-5. doi: 10.1038/nature14587. Epub 2015 Jul 13.
Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R, Le Bourhis X.
Stem Cells. 2015 Feb;33(2):342-53. doi: 10.1002/stem.1849.
MARJORIE LAPOUGE 2014-2015
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Fitamant J1, Kottakis F1, Benhamouche S2, Tian HS3, Chuvin N3, Parachoniak CA1, Nagle JM3, Perera RM1, Lapouge M3, Deshpande V4, Zhu AX5, Lai A6, Min B6, Hoshida Y7, Avruch J8, Sia D9, Campreciós G7, McClatchey AI4, Llovet JM10, Morrissey D6, Raj L6, Bardeesy N11.Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00173-4. doi: 10.1016/j.celrep.2015.02.027
CHARLENE NIOGRET 2014-2015
Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho PC, Oxenius A, Guarda G.
Nat Immunol. 2018 Aug;19(8):809-820. doi: 10.1038/s41590-018-0144-9. Epub 2018 Jul 2.
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.
Rota G, Niogret C, Dang AT, Barros CR, Fonta NP, Alfei F, Morgado L, Zehn D, Birchmeier W, Vivier E, Guarda G.
Cell Rep. 2018 Apr 3;23(1):39-49. doi: 10.1016/j.celrep.2018.03.026.
Chien WW, Niogret C, Jugé R, Lionnard L, Cornut-Thibaut A, Kucharczak J, Savina A, Salles G, Aouacheria A.
Leuk Res. 2017 Apr;55:41-48. doi: 10.1016/j.leukres.2017.01.010. Epub 2017 Jan 18.
OCTAVIA CADASSOU 2014-2015
Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG.
Nat Commun. 2017 Feb 15;8:14423. doi: 10.1038/ncomms14423.
LUCAS BARTHLY 2015-2016
Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T.
Nat Commun. 2016 Dec 7;7:13600. doi: 10.1038/ncomms13600.
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.
Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TN, Lo RS, Ribas A.
N Engl J Med. 2016 Sep 1;375(9):819-29. doi: 10.1056/NEJMoa1604958. Epub 2016 Jul 13.
AHLIMA ROUMANE 2015-2016
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Kottakis F1,2,3, Nicolay BN1,3, Roumane A1,2,3, Karnik R4,5,6, Gu H4,5,6, Nagle JM1,2,3, Boukhali M1,3, Hayward MC7, Li YY8,9, Chen T8,9,10, Liesa M11,12, Hammerman PS8,9,13, Wong KK8,9,10, Hayes DN7, Shirihai OS11,12, Dyson NJ1,3, Haas W1,3, Meissner A4,5,6, Bardeesy N1,2,3. Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31.
Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells. Roumane A1, Berthenet K1,2, El Fassi C1, Ichim G3,4. BMC Cell Biol. 2018 Jul 4;19(1):11. doi: 10.1186/s12860-018-0164-1.
IULIA REVENCO 2016-2017
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Patra KC1,2, Kato Y1, Mizukami Y1,3,4, Widholz S1, Boukhali M1, Revenco I1, Grossman EA5, Ji F6,7, Sadreyev RI1,8,9, Liss AS1, Screaton RA10,11, Sakamoto K12,13, Ryan DP1,2, Mino-Kenudson M1,8,9, Castillo CF1,14,15, Nomura DK5, Haas W1, Bardeesy N16,17.
Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25.
ALINE RENOULT 2016-2017
Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma. Bissey PA1, Law JH2, Bruce JP1, Shi W1, Renoult A3, Chua MLK1,4,5,6, Yip KW1, Liu FF7,8,9. Oncogenesis. 2018 May 22;7(5):40. doi: 10.1038/s41389-018-0050-x.
KARINE LEVEQUE 2016-2017
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K.
Carcinogenesis. 2018 May 3;39(5):652-660. doi: 10.1093/carcin/bgy026.
ANTHONY STEPHANOU 2016-2017
Arai J, Goto K, Stephanou A, Tanoue Y, Ito S, Muroyama R, Matsubara Y, Nakagawa R, Morimoto S, Kaise Y, Lim LA, Yoshida H, Kato N.
J Gastroenterol Hepatol. 2018 May;33(5):1075-1081. doi: 10.1111/jgh.14029. Epub 2018 Feb 6.
PAULINE GENTAZ 2017-2018
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Bird TG1,2,3, Müller M4, Boulter L2,5, Vincent DF4, Ridgway RA4, Lopez-Guadamillas E6, Lu WY2, Jamieson T4, Govaere O7, Campbell AD4, Ferreira-Gonzalez S2, Cole AM4, Hay T8, Simpson KJ2, Clark W4, Hedley A4, Clarke M9, Gentaz P4, Nixon C4, Bryce S4, Kiourtis C4,10, Sprangers J4, Nibbs RJB9, Van Rooijen N11, Bartholin L12, McGreal SR13, Apte U13, Barry ST14, Iredale JP3,15, Clarke AR16, Serrano M6,17, Roskams TA7, Sansom OJ4,10, Forbes SJ2,3.
Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230
→ Projets étudiants
2018-2019
L'alimentation, un allié pendant le traitement - Michel KAHI, Célia MARUEJOULS, Valentin THEVIN
LivretAlimentationCancerMC2017-2018
Projet C.R.A.C. - Marion Muller, Richard MIALLOT, Benjamin ESTAVOYER
Dis Maman pourquoi t'es malade - Fabiana IZAGUIRRE, Fanny BAILLAT, Caroline FEZELOT
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