French versionMASTER of Cancer bioengineering
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The Master 2 Bioengineering, thanks to a transdisciplinary approach and industrial partnerships, aims to give students the practical and theoretical tools to understand and reproduce the physico-chemical complexity of cancers. It trains bioengineers and researchers capable of proposing innovative solutions for cancer models of scientific and therapeutic utility. |
→ First semester teaching units (30 ECTS)
- Physical and chemical complexity of tumors - 3 ECTS
This course wil describe the tumor microenvironment with an emphasis on its physical and chemical heterogeneity. We will insist from a biologist point of view on the importance of physical parameters in the regulation of the hallmarks of tumors.
✉ Responsible for teaching unit : Olivier Meurette (Olivier .meurette@lyon.unicancer.fr)
⊕ Time Distribution : 12h Lecture | 12h Praticals
❝❞ Languages : French and/or English
- Physics of Life - 3 ECTS
This course proposes to highlight the physical principles that play important roles at multiple scales of biological systems (molecules, cells and tissues). It will allow students to grasp new concepts that are now necessary for the understanding of many biological processes and for the development of new model systems.
✉ Responsible for teaching unit : Jean-Paul Rieu et Sylvain Monnier (jean-paul.rieu@univ-lyon1.fr; Sylvain.monier@univ-lyon1.fr)
⊕ Teaching modalities : 12h Lecture | 12h Praticals
❝❞ Languages : French and English
- innovative in vitro models - 3 ECTS
The different in vitro models allowing to take into account the different elements of the tumor microenvironment will be presented, from 2D models to ex-vivo models. The courses will be given in English
✉ Responsible for teaching unit : Charlotte Rivière et Cédric Chaveroux (Charlotte.rivière@univ-lyon1.fr; Cédric.chaveroux@lyon.unicancer.fr)
⊕ Teaching modalities : 12h Lecture | 12h Praticals
❝❞ Languages : French and English
- quantitative approach in biology - 3 ECTS
Introduction to big data generated by genomics and proteomics, introduction to programming with Python to analyze data automatically.
✉ Responsible for teaching unit : Hélène Delanoë-Ayari (helene.delanoe-ayari@univ-lyon1.fr)
⊕ Teaching modalities : 5h Lecture | 20h Praticals
❝❞ Languages : French and English
- Transversal project- 3 ECTS
The aim of this course is to apply the knowledge of the other compulsory courses to an industrial and/or biological problem. It will initiate the students to the global implementation of a new device (design, implementation, means of analysis). The course will be in English.
✉ Responsible for teaching unit : Charlotte Rivière (Charlotte.rivière@univ-lyon1.fr)
⊕ Teaching modalities : 5h Lecture | 20h Praticals
❝❞ Languages : French and English
- English for professional communication - level 2 - 3 ECTS
✉ Responsible for the teaching unit : Joann PIGAT (joann.pigat@univ-lyon1.fr )
⊕ Teaching modalities : 30h DG
❝❞ Languages : English
✎ Evaluation methods: continuous monitoring (100%)
→ Second semester teaching units (30 ECTS)
- Laboratory internship - 27 ECTS
✉ Responsible for teaching unit : Charlotte Rivière(charlotte.riviere@univ-lyon1.fr)
✎ Evaluation methods : Internship report like scientific publication | Oral presentation
→Optional teaching unit - 3 in the two semester for 9 ECTS
- Optional teaching unit - 3 in the two semester for 9 ECTS
Choose 1 teaching unit
- Environmental factors and carcinogenesis - 6 ECTS
Study of environmental, occupational and nutritional factors and exploration of associated molecular mechanisms. The teaching unit address the fundamentals between environment and cancer, the introduction to health / environment, the criteria of causality and classification of carcinogenic substances as well as the different methods for the environmental factors study.
✉ Responsible for teaching unit : Béatrice FERVERS (beatrice.fervers@lyon.unicancer.fr)
⊕ Time distribution : 44h Lecture| 16h G
❝❞ Languages : French and english
✎ Evaluation methods : Lecture : written exam (75%) | DG : oral (25%)
or 2 teaching units (3 ECTS) among :
- Aging and Cell Death - 3 ECTS
Biology of cell death: necrosis, necroptosis, apoptosis and autophagy and their relationship to aging Cellular senescence: molecular mechanisms of control and escaping. Cellular aging and damage to molecules: reactive oxygen species, proteins, nucleic acids Cellular aging and metabolism: theories of caloric restriction, metabolic signalling pathways Physiopathology of aging: organisms longevity, aging diseases and neurodegenerative diseases
✉ Responsible for teaching unit : Carole KRETZ (Carole.Kretz@univ-lyon1.fr)
⊕ Time distribution : 13h Lecture | 5h DG
❝❞ Languages : English and French
✎ Evaluation methods : Oral presentation (75%) | continuous monitoring (25%)
- Biostatistics et Bioinformatics - 3 ECTS
6 hours of courses in which the main biostatistical tools are discussed, 24 hours of practical work focused on the search for sequence homologies (blast) of analysis, the construction of phylogenetic trees, the putting into experimental situations, statistics design, etc.
✉ Responsible for teaching unit : Raquel TAVARES (Raquel.Tavares@univ-lyon1.fr)
⊕ Time distribution : 6h Lecture | 24h Laboratory
❝❞ Languages : French
✎ Evaluation methods : Final exam
- Level 1 animal experimentation accreditation (CPUAFS) - 3 ECTS
This training will take place at the veterinary school of Lyon (VetAgro Sup campus - Marcy l'étoile) The goal is to allow students who wish to validate the Level 1 animal experimentation by continuing the study of animal models started in the first year of master of oncology.
Spontaneous models in experimental oncology: oncogenesis, specificities related to the domestic animal, specificities of the clinical veterinary oncology framework, ethical regulation, design and implementation of pre-clinical and clinical tests in animals, animal samples and tumor banks and quality system.
✉ Responsible for teaching unit : Delphine GREZEL (delphine.greze@vetagro-sup.fr)
⊕ Time distribution : 15h lecture |15 h DG
❝❞ Languages : French
✎ Evaluation methods : Final written exam (100%)
- Focused destruction of cancer - 3 ECTS
✉ Responsible for teaching unit: Frédéric PADILLA ( frederic.pad@gmail.com)
Michel RIVOIRE (michel.rivoire@lyon.unicancer.fr)
⊕ Time distribution : 20 h Lecture | 5h DG
❝❞ Languages : French. Courses material in english
✎ Evaluation methods : Final written exam (100%)
- Drug Delivery + additional memory- 3 ECTS
The objective of this course is to introduce students to the use of nanotechnology for the development of new types of contrast agents and drugs that specifically target cancer cells for diagnostic and therapy purposes (theranostics).
The course is divided into four parts:
1- General introduction, principle and hopes,
2- How to design nanoparticles for imaging, vectorization and drug delivery?
3- Medical imaging.
4- Vectorization and therapy.
✉ Responsible for teaching unit : Charlotte Rivière (charlotte.riviere@lpmcn.univ-lyon1.fr)
⊕ Time distribution: 10hDG
❝❞ Languages : English
✎ Evaluation methods : Mid-term evaluation and oral presentation of scientific publication
- Health economy and cancer - 3 ECTS
Different topics will be covered: Health Systems (HMS), Health Expenditure (NM) Health Expenditure Control, Health Care Supply (NM and HMS), Health Professionals (NM), Health Institutions (HMS), and an introduction to the medico-economic evaluation
✉ Responsible for teaching unit : Nora MOUMJID (nora.moumjid@univ-lyon1.fr)
Carole Siani (carole.siani@univ-lyon1.fr)
and Hans‐Martin SPATH (Hans-Martin.Spath@adm.univ-lyon1.fr)
⊕ Time distribution : 24h Lecture | 6h DG
❝❞ Languages : French
✎ Evaluation methods : Written final exam - Courses (66.67%) | Oral presentation - Practical Work (33.33%)
- Emerging concepts in functional genomics - 3 ECTS
The themes are renewed each year by a steering committee made up of different teachers from the teaching unit, according to the evolution of knowledge in the field of functional genomics, molecular genetics and cell physiology.
✉ Responsible for teaching unit : Jérome LAMARTINE ( jerome.lamartine@univ-lyon1.fr)
⊕ Time distribution : 10h Lectures | 8h DG
❝❞ Languages : English
✎ Evaluation Methods : preparation of a research project related to the theme of the course (80%) + note of participation of students in scientific discussions (20%)
- Immunology & Cancer - 3 ECTS
- anti-tumor immune response and its manipulation
Action mechanisms of carcinogens of infectious origin; the "multi-hit-multi-step" or step progression of cancerization; the antigenic profile of the tumor cells; molecular analysis of the tumor microenvironment; Functional alterations of immune system cells infiltrating tumors
- Immune system cancers
Panorama and specificity within cancers; analysis of the immune response after immunotherapy; tumor escape mechanisms; monoclonal antibodies in cancer immunotherapy; Hematopoietic stem cell transplantation as a model for immunotherapy
- the protection of patients immunosuppressed by treatments or following an infection.
Cytokine action mechanisms capable of restoring immune functions during chemo or radiotherapy; concept of secondary cancer and state of research on the parameters useful for monitoring the occurrence of an infection or cancer on models of studies relating to organ or blood donation, patients infected by HIV or HCV, to patients immunosuppressed by treatment following a transplant or primary cancer.
✉ Responsible for teaching unit : Christine DELPRAT (christine.delprat@univ-lyon1.fr)
⊕ Time distribution : 18h Lecture
❝❞ Languages : English
✎ Evaluation methods : Courses : final written exam (50%) + oral presentation (50%)
- Metastasis, Migration et EMT- 3 ECTS
✉ Responsible for teaching unit : Chantal Diaz (chantal.diaz@univ-lyon1.fr)
⊕ Time distribution : 20h Lecture | 10h DG
❝❞ Languages : French
✎ Evaluation methods : Lecture: written exam (100%)
- Think cancer in the light of the patient himself - 3 ECTS
Bring humanities and social sciences into the scientific training as a complement. Put into action the national guidelines of the CNIB. Contribute to a perspective of the Descartes epistemology from which science comes to understand its strengths and limitations
✉ Responsible for teaching unit : Romain PARENT (romain.parent@inserm.fr)
⊕ Time distribution : 25 h DG
❝❞ Languages : French
✎ Evaluation methods : Dissertation (10 pages) deadline : june
- Pharmaceutical industries strategy and technologies MED- 3 ECTS
Teaching unit from IAE School. Scheduled between November and February
✉ Responsible for teaching unit: Corinne Montoya
⊕ Time distribution : 46h lecture
❝❞ Languages : Not mentionned by the responsible
✎ Evaluation methods : Not mentionned by the responsible
- Tissue and cell engineering + additional memory- 3 ECTS
Lecture part
A) Phenotypic and Mechanical characterization of cells and tissues – force, adhesion and motility studies - microsystems for cell culture, diagnosis, drug screening… : 8 hours
B) Biomaterials and scaffolds able to finely tune various cell responses : 6 hours
Practical part
C) Basics of Image Analysis
-3 theoretical courses with examples on a free software Image J -3 courses for developing a project in tandem : tracking endothelial cells on patterned surfaces.
✉ Responsible for teaching unit : Jean-Paul RIEU (jean-paul.rieu@univ-lyon1.fr)
⊕ Time distribution : 10h Lecture | 12h DG
❝❞ Language : English
✎ Evaluation methods : Lecture : Bibliographic assay (50%) + Projet Report (50%)